It is no exaggeration to say that motivational interviewing (MI) has transformed the culture of clinical practice and the way healthcare practitioners and researchers understand behavior change. MI, as an empirically supported therapeutic approach, has grown all across prevention, intervention, treatment, and research settings. Nowhere is the need to target behavior change more urgent than in people living with HIV. MI is a collaborative, person-centered clinical method that fosters a constructive practitioner-patient relationship and facilitates behavior change through eliciting and strengthening motivation for change. MI can be implemented as a stand-alone brief intervention, a prelude to treatment, or a platform for ongoing care. While MI has been shown to promote behavior change in a variety of healthcare settings and health behaviors in diverse cultures and communities, from substance use, safer sex, physical activity, medication and treatment adherence, more recently there has