This book presents contextualised and detailed research on Artificial Intelligence (AI) and the Global South. It examines the key challenges of these emerging and least industrialised countries while proffering holistic and comprehensive solutions. The book then explains how AI, as part of these broad interventions, can drive Global South economies to achieve inclusive development and shared prosperity. The book outlines how countries can swiftly prepare to adopt and develop AI across all sectors. It presents novel national, regional, and continental AI adoption, development, and implementation frameworks. Features: * Broad non-AI interventions and prescriptions to address Global South challenges * A comprehensive but accessible introduction to AI concepts, technology, infrastructure, systems, and innovations such as AlphaFold, ChatGPT-4, and DeepSeek-R1 * An overview of AI-related technologies such as quantum computing, battery energy storage systems, 3D printing, nanotechnology,